2026-10-25T18:59:52Zhttps://api.arca.fiocruz.br/oai/request

oai:arca.fiocruz.br:icict/114882026-10-19T21:52:26Zcom_123456789_2com_icict_1956col_icict_156col_icict_1957

Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome Almeida, Vinicius Cotta de Dupré, Löic Guipouy, Delphine Vasconcelos, Zilton Farias Meira de Motilidade ANATOMIA [A]::Células::Estruturas Celulares::Espaço Intracelular::Citoplasma::Estruturas Citoplasmáticas::Citoesqueleto::Citoesqueleto de Actina ANATOMIA [A]::Células::Células Sanguíneas::Leucócitos::Leucócitos Mononucleares::Linfócitos::Linfócitos T Over the last decades, research dedicated to the molecular and cellular mechanisms underlying primary immunodeficiencies (PID) has helped to understand the etiology of many of these diseases and to develop novel therapeutic approaches. Beyond these aspects, PID are also studied because they offer invaluable natural genetic tools to dissect the human immune system. In this review, we highlight the research that has focused over the last 20 years on T lymphocytes fromWiskott–Aldrich syndrome (WAS) patients.WAS T lymphocytes are defective for the WAS protein (WASP), a regulator of actin cytoskeleton remodeling. Therefore, study of WAS T lymphocytes has helped to grasp that many steps of T lymphocyte activation and function depend on the crosstalk between membrane receptors and the actin cytoskeleton. These steps include motility, immunological synapse assembly, and signaling, as well as the implementation of helper, regulatory, or cytotoxic effector functions. The recent concept that WASP also works as a regulator of transcription within the nucleus is an illustration of the complexity of signal integration in T lymphocytes. Finally, this review will discuss howfurther study ofWAS may contribute to solve novel challenges of T lymphocyte biology. 2015-08-19T13:49:20Z 2015-08-19T13:49:20Z 2015 journal article ALMEIDA, Vinicius Cotta de et al. Signal integration duringT lymphocyte activation and function: lessons from the Wiskott–Aldrich syndrome. Frontiers in Immunology, v. 6, Article 47, p. 1-11, Feb. 2015. 1664-3224 https://arca.fiocruz.br/handle/icict/11488 10.3389/fimmu.2015.00047 eng open access application/pdf University of Washington