2026-10-25T15:48:47Zhttps://api.arca.fiocruz.br/oai/requestoai:arca.fiocruz.br:icict/161072026-07-24T18:50:26Zcom_icict_3790com_icict_8371col_icict_9624col_icict_8372
Synthesis and Antibacterial Activity of Alkylated Diamines and Amphiphilic Amides of Quinic Acid Derivatives
Rezende Júnior, Celso de Oliveira
Oliveira, Larissa A.
Oliveira, Bruno A.
Almeida, Camila G.
Ferreira, Bianca S.
le Hyaric, Mireille
Carvalho, Guilherme S. L.
Lourenço, Maria Cristina S.
Batista, Michel
Marchini, Fabrício Klerynton
Silva, Vania L.
Diniz, Claudio G.
Almeida, Mauro Vieira de
FAPEMIG, CNPq, CAPES.
Different series of N-alkylated diamines and their derivatives condensed to quinic acid were synthesized and tested for antibacterial properties against Staphylococcus aureus, Staphylococcus epidermidis, Pseudomonas aeruginosa, and Mycobacterium tuberculosis. The lipophilic chain and carbohydrate moiety modulate the antibacterial activity and the compounds showed a structure-activity relationship. Overall, 11 compounds displayed better activity than chloramphenicol against Gram-positive and Gram-negative bacteria. Monoalkylated amines 2a-h displayed an activity similar to that of ethambutol against Mycobacterium tuberculosis.
2016-10-05T19:10:45Z
2016-10-05T19:10:45Z
2015
journal article
REZENDE JÚNIOR, Celso de Oliveira et al. Synthesis and Antibacterial Activity of Alkylated Diamines and Amphiphilic Amides of Quinic Acid Derivatives. Chemical Biology and Drug Design, v. 86, n. 3, p. 344-350, Sept. 2015.
1747-0277
https://arca.fiocruz.br/handle/icict/16107
10.1111/cbdd.12498
eng
restricted access
application/pdf
David Selwood