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Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy D'Avila, Heloisa Almeida, Patrícia E. Roque, Natália R. Faria Neto, Hugo Caire C. Bozza, Patrícia T. Influxo de Eosinófilos Eotaxina Mycobacterium bovis BCG Pleurisia Receptor C-C Mediado por Quimiocina Acesso aberto em 20/04/2020 - https://iai.asm.org/content/iai/75/3/1507.full.pdf An acute and persistent eosinophil infiltration is observed during Mycobacterium bovis BCG pleural infection in mice. Eosinophil accumulation, lipid body formation, and eotaxin production were significantly reduced in BCG-infected Toll-like receptor-2 (TLR2)-deficient mice compared to wild-type mice. Neutralization of eotaxin or CCR3 drastically inhibited BCG-induced eosinophil accumulation and lipid body formation, indicating that BCG-induced eosinophil recruitment and activation is largely dependent of TLR2-mediated eotaxin generation. 2020-01-01 2020-04-20T19:08:11Z 2020-04-20T19:08:11Z 2007 journal article D`ÁVILA, Heloisa et al. Toll-Like Receptor-2-Mediated C-C Chemokine Receptor 3 and Eotaxin-Driven Eosinophil Influx Induced by Mycobacterium bovis BCG Pleurisy. Infection and Immunity, v. 75, n. 3, p. 1507-1522, Mar. 2007. 0019-9567 https://arca.fiocruz.br/handle/icict/40900 10.1128/IAI.01326-06 1098-5522 eng open access application/pdf American Society for Microbiology