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Graphene quantum dots decorated with imatinib for leukemia treatment Felix, Daniele Mendes Alencar, Luciana Magalhães Rebelo Menezes, Frederico Duarte de Midlej, Victor do Valle Pereira Aguiar, Lorayne Piperni, Sara Gemini Zhang, Jian Liu, Yin Ricci Junior, Eduardo Alexis, Frank Alves Junior, Severino Zhu, Lin Oliveira, Ràlph Santos Entrega de medicamentos Ponto quântico de grafeno Dispositivo biomédico Material inteligente Nano-partícula COMPOSTOS QUÍMICOS E DROGAS [D]::Substâncias Macromoleculares::Materiais Inteligentes 03 Saúde e Bem-Estar The use of graphene quantum dots as biomedical device and drug delivery system has been increasing. This nano platform of pure carbon has showed unique properties and showed to be safe for human use. The imatinib is a molecule designed to specifically inhibit the tyrosine kinase, used for leukemia treatment. In this study, we successfully decorated the graphene quantum dots (GQDs@imatinb) by a carbodiimide crosslinking reaction. The GQDs@imatinb were characterized by FTIR and AFM. The nanoparticles' in vitro behaviors were evaluated by cellular trafficking (internalization) assay and cell viability and apoptosis assays in various cancer cell lines, including suspension (leukemia) cells and adherent cancer cells. The results showed that the incorporation of the imatinib on the surface of the graphene quantum dots did not change the nanoparticles' morphology and properties. The GQDs@imatinb could be efficiently internalized and kill cancer cells via the induction of apoptosis. The data indicated that the prepared GQDs@imatinb might be a great drug nano-platform for cancer, particularly leukemia treatments. 2021-05-01T19:03:30Z 2021-05-01T19:03:30Z 2021 journal article FELIX, Daniele Mendes et al. Graphene quantum dots decorated with imatinib for leukemia treatment. Journal of Drug Delivery Science and Technology, v. 61, 102117, 7p, Feb. 2021. 1773-2247 https://arca.fiocruz.br/handle/icict/46999 10.1016/j.jddst.2020.102117 eng restricted access application/pdf Elsevier